Knowledge Center

The Value of Our Clinical Osmometers

Our tradition of high-quality osmometers continues with new advanced features for the current laboratory environment.

Our newest model, the OsmoPRO® MAX Automated Osmometer, offers the greatest workflow efficiency with complete walkaway testing. The single-sample Osmo1® and multi-sample OsmoPRO® deliver the high precision and accuracy of previous models but also provide improved ease-of-use and enhanced data management.  Use our library of resources to compare your current model with the features, videos, data, and support options now available with our clinical portfolio of products.

User-Friendly Features

  • Small sample volumes improve test flexibility
  • Flexible user settings increase patient data security and integrity
  • On-board printer and network connectivity enable simpler reporting
  • Automated cleaning on multi-sample instruments reduces hands-on time
  • Primary tube loading on the OsmoPRO MAX allows full walk-away testing

Gold Standard Technology

Our osmometers rely on our gold-standard freezing-point depression technology to provide the patient results you’ve come to trust.

  • Freezing point depression osmolality measurement
  • 2- or 3-point calibration
  • On-board Levey-Jennings charts
Learn more about our Freezing Point Technology.

Support Options

Advanced Instruments provides excellent support for your osmolality testing. We are ready to help you with the seamless integration and validation of your upgraded instrument.

Learn more about our clinical lab services.

Osmo1® Single-Sample Micro-Osmometer vs. Model 3320 Osmometer

The discontinued Advanced Instruments Model 3320 Osmometer has been a trusted instrument in thousands of laboratories around the world. In this short video, we will introduce you to our next-generation single-sample micro-osmometer, the Osmo1, and compare the old with the new.

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OsmoPRO® Multi-Sample Micro-Osmometer vs. Model 2020 Osmometer

The discontinued Advanced Instruments Model 2020 Osmometer has been a trusted instrument in thousands of laboratories around the world. In this short video, we will introduce you to our next-generation multi-sample micro-osmometer, the OsmoPRO, and compare the old with the new.

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Osmo1® Single-Sample Micro-Osmometer vs. 3250 Single-Sample Osmometer

The discontinued Advanced Instruments 3250 Single-Sample Osmometer has been a trusted instrument in thousands of laboratories around the world. In this short video, we will introduce you to our next-generation single-sample micro-osmometer, the Osmo1, and compare the old with the new.

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Osmo1® Single-Sample Micro-Osmometer vs. Fiske 210 Single-Sample Micro-Osmometer

The discontinued Advanced Instruments Fiske 210 Single-Sample Micro-Osmometer has been a trusted instrument in thousands of laboratories around the world. In this short video, we will introduce you to our next-generation single-sample micro-osmometer, the Osmo1, and compare the old with the new.

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Clinical Validation Comparison: Osmo1®
Single-Sample Micro-Osmometer Versus Model 3250 Single-Sample Osmometer

The Osmo1® Single-Sample Micro-Osmometer is the replacement for the Model 3250 Single-Sample Osmometer which was discontinued in 2020. The Osmo1 provides additional benefits over the Model 3250 including but not limited to a touchscreen display for ease-of-use, integrated barcode scanning, a small 20 µL sample size and the elimination of heat transfer fluid. This paper summarizes a study comparing the performance of the Osmo1 and Model 3250 osmometers. In the study, the Osmo1 exhibited no significant performance difference compared to the Model 3250 and met all acceptance criteria for linearity, precision and accuracy.

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Current Clinical Osmometers

OsmoPRO® Multi-Sample Micro-Osmometer

Supporting efficient workflows for mid-to high-volume clinical chemistry labs, the OsmoPRO features a convenient carousel design that handles up to 20 samples, an intuitive touchscreen interface, and industry-leading performance. With a 90 second test time and onboard QC charts the OsmoPRO helps your laboratory stay productive. Simple, reliable, and efficient, the OsmoPRO delivers accurate and precise analysis of patient samples for maximum productivity.

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Osmo1® Single-Sample Micro-Osmometer

With the Osmo1 Single-Sample Micro-Osmometer, we’ve bundled together accurate and reliable osmolality measurement with ease-of-use for efficient patient sample analysis. With a 90 second test time and onboard QC charts the Osmo1 helps your laboratory stay productive. Easily maintain regulatory compliance while ensuring the security and integrity of patient data with the Osmo1. Best for labs that process 10 or fewer samples per day or prefer a direct-draw instrument.

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OsmoPRO® MAX Automated Osmometer

Built for clinical laboratories of all sizes, the OsmoPRO MAX delivers unprecedented automation, ease of use, and efficiency. Innovative flow-through technology revolutionizes osmolality testing by eliminating manual pipetting and consumables. With the OsmoPRO MAX, sample pipetting, testing, and cleaning are performed automatically by the device. Continuous loading and unloading allows your staff to begin tests as soon as samples come in, removing the need to batch test. The OsmoPRO MAX goes beyond providing accurate and precise test results to deliver a simplified osmolality testing workflow that today’s clinical laboratories seek.

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Related Resources

Learn more by checking out our additional educational resources below.

Clinical Case Study

Osmolality: A Powerful Tool in Bioprocessing

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Clinical Case Study

Osmolality Testing For Patch-Clamp Studies

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Clinical Case Study

Clinical Reference Laboratory (CRL) When “every sample is a life trusted to our care”

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Clinical App Note

The Value of Osmolality Testing

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Clinical App Note

The Importance of Measured Osmolality Testing With an In-house Osmometer

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Clinical App Note

The Critical Role of Osmolality in Improving Health and Economic Outcomes in Patients with Hyponatremia

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Clinical Webinar

Impact Of Osmolality During The AAV Manufacturing Workflow

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Clinical Webinar

AUDIO: A Conversation with the CAP on Osmometer Quality Control

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Clinical Webinar

Freeing Up Tech Time Advances in Osmolality Testing

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Clinical Posters

Shining Renewed Light on a Tried-and-True Test: The Critical Role of Osmolality Testing in Improving Health and Economic Outcomes in Patients with Hyponatremia

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Clinical Posters

Pipetting Viscous Solutions

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Clinical Posters

Improving cell count turnaround times with the GloCyte® Automated Cell Counter for CSF

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Clinical Knowledge Center

What is osmolality?

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Clinical Knowledge Center

Osmometers – Principle, types & uses

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Clinical Knowledge Center

Osmolality Testing

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