CELL LINE DEVELOPMENT

The STUDIUS® software is very intuitive and user-friendly. The images are of very good quality with the different focus planes. Overall, using the VIPS PRO is very intuitive.

Before this instrument, all our clonal analysis was done manually. We used to spend hours on the microscope looking for wells containing colonies possibly derived from single cells. Now, everything is automated, we since we can track the cell growth over time, we can be absolutely sure that a particular clones is derived from a single cell.

Very easy to use and produces good quality cell images, which are essential when monitoring outgrowth after limiting dilutions. The 10 plate cassette with automatic loading is very helpful for high throughput experiments, and the versatility of plate type makes the cell metric even more useful.

The Cell Metric was designed with the end user in mind. Setup and use are easy and the ability to generate a clonality report at the end of a project is fantastic. I would highly recommend taking a very close look at the Cell Metric before adding any imaging system to a CLD workflow.

The Solentim Cell metric has become a crucial instrument in our cell line development process. The instrument has allowed us to create reliable and consistent data which in turn results in us being able to track our cell lines and compare them to each other with ease. Images produced by this instrument are always of high quality, and it is easy to train new member of the team on this platform as the system is very user-friendly! ...The instrument is certainly worth the money we paid as it has allowed us to determine monoclonality and track colony growth ...

During expansion, we use InstiSHAKE CHO to support the adaptation of our clones to shaking culture. Thanks to InstiSHAKE CHO, we have significantly reduced the number of clones lost (by 90%) and have reduced the amount of time taken for cells to reach our desired viable cell density and viability by 7 days.  Taken together, the combined use of InstiGRO CHO and InstiSHAKE CHO can accelerate our CLD workflow up to 3 weeks with little compromise to productivity. 

We use InstiGRO CHO to improve the efficiency of our cloning projects. The supplement has helped us achieve clonal outgrowth >80% and has reduced the time taken for clones to reach our desired confluence by 2 weeks! Taken together, the combined use of InstiGRO CHO and InstiSHAKE CHO can accelerate our CLD workflow up to 3 weeks with little compromise to productivity. 

[With the VIPS PRO], we can trace back the data to the single cell, select from our top 48 cell lines, and report all the information – our proof of monoclonality is already in there, and that’s really nice.

The Enhanced Clonality Reports easily generated by the VIPS/Cell Metric software allows us to track both cells and potential debris from first inception of the single cell in the well, to full-grown colonies enabling us to provide our customers with full traceability and audit trail of each cell line we produce for them with a single, well-crafted document.

The VIPS™ is unique, being the only single cell cloning system on the market that tracks a single cell’s arrival in the actual well with high resolution (z-stack) imaging and to support the subsequent daily whole well imaging provided by the Cell Metric.

The VIPS system allowed us to shave off a few months from our development timeline and select highly stable single clones for manufacturing purposes.

The VIPS™ system and software has helped our company to deliver a high-quality data-package that meets global regulatory standards...The ease of use and reliability of the VIPS freed up valuable time.

Cell Metric had the best whole-well imaging capabilities and clonality reports and, when we demoed the instrument, we were convinced by the robustness of the system and very high image quality.

The Solentim ecosystem, [VIPS , Cell Metric, ICON], allowed Wheeler to rapidly develop and launch a standardized cell line development service that is integrated with a scalable drug substance process.