Bioprocessing Industry

Process Development

Optimizing biologics process development.

Optimizing Your Development

Biopharmaceutical development and manufacture involves many complex steps. These processes must consistently produce a biopharmaceutical product of predetermined yield, purity, and quality.

To optimize your manufacturing processes, osmolality can be used to monitor cell culture and fermentation to ensure optimal cell health, and consequently, high product quality and yield.

Ensuring Downstream Efficiency

Osmolality can help ensure that every step in your biologics process development is optimized, such as monitoring cell culture and fermentation to ensure optimal cell health, and consequently, high product quality and yield.

It can also deliver confidence during high filtration recovery steps like Ultrafiltration/diafiltration (UF/DF) and tangential flow filtration (TFF). This helps provide precise buffer preparation and proves complete buffer exchange to improve purification efficiency while safeguarding your biologics as it passes through storage, reconstitution, and injection.

 

Ensure Quality Fill & Finish

Within the fill and finish stage there are guidelines when it comes to a release specification of a product.

Osmolality is a critical parameter for final release of a parenteral drug due to the implications of an out-of-specification formulation on a patient.

Laboratories must both identify and then adhere to their own specifications, thus minimizing any potential side effects an  out-of-specification injectable may cause.

Reducing Time to Market

Shortening time to market is not only critical to meet demand, but it is also essential to stay ahead of competitors. Automating and taking control of your assay workflows can make your process more efficient by breaking down the assay workflow into modules that are individually optimized – therefore improving end-to-end assay performance. 

Verifying the performance of your automated liquid handling instruments as often as needed, identifying trends before failures happen, and avoiding costly downtime is critical to make this happen. Our technology can help. 

Optimize Cell Culture Conditions to Maximize Cell Density and Yield

Osmolality, the measurement of total solute concentration, can help save time and money by delivering information throughout your biologics process development.

Access our Popular Educational Resources

Learn more about how to utilize osmolality to improve your process development workflow - check out our comprehensive educational resources.

Bioprocessing Case Study

Osmolality: A Powerful Tool in Bioprocessing

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Bioprocessing Case Study

SEKISUI XenoTech ensures quality and productivity with the MVS

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Bioprocessing Case Study

Osmolality Testing For Patch-Clamp Studies

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Bioprocessing App Note

Advanced Instruments OsmoTECH® HT Micro-Osmometer: Delivering Reliable Performance of Osmolality Testing with High Throughput Automation

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Bioprocessing App Note

White Paper: Process Optimization for Assays: A Framework for Controlling Variability and Optimizing Assay Performance

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Bioprocessing App Note

Reliable Osmolality Testing of High Concentration mAb Formulations

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Bioprocessing Webinar

Maximize the potential of your high throughput upstream chemistry analyzer with new osmolality applications

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Bioprocessing Webinar

Adjusting Pipetting Variables to Optimize Methods

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Bioprocessing Webinar

Increase Productivity & Predictability in Upstream Applications

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Bioprocessing Posters

Product In Action – OsmoTECH® HT Automated Micro-Osmometer

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Bioprocessing Posters

Osmolality in Bioprocessing Applications Throughout the Full Workflow

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Bioprocessing Posters

Pipetting Viscous Solutions

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Bioprocessing Knowledge Center

What is osmolality?

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Bioprocessing Knowledge Center

Labware Considerations

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Bioprocessing Knowledge Center

Freezing Point Depression Theory

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Associated Products

Bioprocessing Services

Get the best performance from your instruments from the experts who designed them. We provide a range of services and service plans to meet your specific needs.

Our certified Field Service Engineers provide on-site, professional installation, training, validation, and system maintenance support.

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We had a demo of the [OsmoTECH PRO] instrument after seeing it at BPI East. The sales managers were prompt in setting up a lunch and learn. The instrument itself was very easy to run samples on and allowed for true load and walk away functionality. The sales managers were thorough professionals, waiting for our PO to go through and working with us to ensure we received the item within a week of ordering. It has the ability to run 20 samples at a time and is great value for the money spent.

Kanaka Bhere

Boehringer Ingelheim Animal Health

The Artel MVS simplifies fluid verification of all automated liquid handlers and multichannel pipettes. The system is fast, calculates all plate and well statistics (Relative Inaccuracy, Coefficient of Variation, Standard Deviation and Mean) and it is simple to set up and use. For all of its capabilities and low-cost point...the MVS is one of the best value purchases I have ever made for my lab.

Mark Orlowski

Pfizer

The [OsmoTECH PRO] instrument is extremely effective, easy to set up and validate, gives quick results and is extremely accurate.

David Longino

Aspek Pak

The Artel MVS makes it so easy to do a monthly verification that the 96 channel CORE head on my Hamilton Vantage is dispensing the correct volumes. Doing the confirmation gravimetrically would be so time consuming, but using the Artel dyes and the MVS makes it something one person can do in a single morning. The software is easy to use, and the instrument has not had any maintenance issues.

Katherine Schneider

Pfizer

The [OsmoTECH PRO] is great for accurate and precise osmolality, giving reliable and reproducible measurements.

Varun Khurana

Glaukos

This [OsmoTECH] instrument was a dream come true. The administrator can lock down features and dictate what users can and cannot do. Very easy to use and extremely reliable instrument.

Troy Franz

Paragon Bioservices

The best part of the [OsmoTECH] instrument is it gives accurate and reproducible results for any solution and most importantly in less than a minute you have the results.

Brijeshkumar Pandya

Nivagen Pharmaceuticals Inc.

[The OsmoTECH] achieves high quality and reproducible results. Easy instrument to use and well-presented software.

Claudia Chadford

Touchlight Genetics

[The OsmoTECH PRO] instrument is simple to operate with minimal consumables.

Greg Hautke

Baxter Healthcare

We use the PCS pipette calibration system. It has always been super reliable and accurate, and we have never had a single issue in the 8 years I have worked with it. The kits containing the solutions for the PCS are customizable, so you don't have to buy solutions you don't need. We do performance checks on our pipettes on a daily basis, so we could not live without it! It makes our jobs so much easier too!

Joan Kozlowski

Fresenius Kabi

The Artel PCS makes checking the pipetting proficiency of new hires quick and easy. It's also great for checking pipettes that may not be functioning properly.

Eric M

Sanofi

The Artel MVS has been a huge help for our lab in validating volumes on new automated liquid handlers. Always gives consistent results, easy to use, software is extremely straightforward, and any time we have an issue, it's super easy to get help from the Artel team. Thank you!

Leah Chong

Invitae

The MVS system is extremely useful for periodic performance QC testing of high-throughput liquid handlers, high-throughput liquid handler calibration, and various liquid handler/single channel pipette tip type/lot QC. The MVS system requires minimal maintenance and MVS manager software is intuitive to use and flexible to set up various plate layouts to meet user’s need. The customer service is very responsive and helpful. They provide a notification for calibrator plate re-certification annually ...

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

The [Artel MVS] product is accurate and reliable. With the addition of the pre-owned models of MVS readers, it also becomes affordable. The expansion of the dye solutions to include MasterMix and Serum along with their original aqueous offering makes Artel a definitive liquid class setup solution. The FSE performing setup and the account manager were on-time, responsive, and supportive during install and (most importantly) afterwards.

Kevin Kim

Avellino Labs

The Artel application scientist is easy to work with, knowledgeable about interpreting test data and giving advice, and flexible to help onsite if needed. I would recommend the Artel MVS because it saves time and material cost. Most important is having a standard method to calibrate different pipettes and optimize liquid class on automated liquid handlers while managing the sources of variability systematically.

Michelle Mak

10x Genomics

This [OsmoTECH PRO] osmometer is an accurate and convenient tool for the needs of our lab. Our lab works in the developmental stage of pharmaceuticals, and requires quick, precise bursts of osmolality checking for QC - and this instrument (with a load capacity of 20 samples) takes care of those needs. With developmental drugs, limited sample volume is often an issue - this instrument only needs 30uL (and takes ~90 seconds a measurement).

Sasha Sheptovitsky

Alexion Pharmaceuticals

Osmolality measurements are easy and reliable with this [OsmoTECH PRO] instrument.

Kevin Kent

Boehringer-ingelheim

[The OsmoTECH PRO is] very easy to use for all technicians in a quality control lab. Small sample size. Friendly technicians that explained how to use the product very well.

Cathy Gladkowski

Biologos LLC

[The OsmoTECH PRO is] very easy to use due to short analysis time and sample preparation.

Karthik Venkatachalam

Pfizer

[The OsmoTECH PRO is a] great system for multiple sample testing. Very straightforward and easy to use.

Bobby Grigoropoulos

Fresenius Kabi USA

[The OsmoTECH XT is] easy to use, reliable and self-navigating options menu.

Alexander Shapiro

Precision NanoSystems

The OsmoTECH PRO is working pretty well so far! ... As far as reproducibility, data integrity, ease of use etc. I think it is a very good upgrade for us! On the whole we’re quite happy, I'd recommend this device to a colleague looking for a new high throughput osmometer.

Sean Clements

Takeda

The OsmoTECH PRO is working pretty well so far! ... As far as reproducibility, data integrity, ease of use etc. I think it is a very good upgrade for us! On the whole we’re quite happy, I'd recommend this device to a colleague looking for a new high throughput osmometer.

Sean Clements

Takeda

The [OsmoTECH] is highly effective and obtained results are of high quality. With this instrument I can develop my formulation for meeting the osmolality criteria for drug products.

Siva Bingi

Intas Pharmaceuticals

[The OsmoTECH is] easy to use and robust piece of equipment that met all our user and regulatory requirements. The hardware is sleek, efficient and easy to use. The integrated software has built in data integrity controls and is thoroughly tested through validation test scripts / reports.

J. Lacey

Replimune

The Artel PCS fulfills our requirements on ISO compliant pipette calibration and testing. Results are reproducible and variance is lower than in manual process. Personnel is easily trained on the device. Process is faster than manual process.

Andreas Heider

Axolabs GmbH

The MVS system is fairly intuitive to use. Not only can we use this for our internal automated liquid handler volume verification, tip test and calibration work, we have been using the system to offer external volume verification service to our collaborators. The system is very durable without significant issues and easy to maintain. MVS reagent orders are always processed and delivered in a timely manner. Our regional specialist periodically checks in to ask if the system is working as expected.

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

The [Artel MVS] is easy to use, gives accurate and reliable results. It's a great way to quickly determine the functioning of the automation systems that we install and maintain.

Thobias Haakman

Beckman Coulter

Equipment was easy to set up and easy to use. The [OsmoTECH HT] runs reliably and is great to have for running many samples.

Monica G

Biotech

[The OsmoTECH PRO is an] excellent product and extremely efficient! Easy to clean and maintain. Excellent customer support and allows increased in-process testing capabilities.

Seth Rindner

Biologos LLC

The [OsmoTECH PRO] is very easy to use. Allows my lab to update a 20+ year old instrument, also from Advanced.

Walter Wasylenko

Baxter Healthcare Corporation

[The OsmoTECH XT is a] robust and versatile instrument that meets all of our osmolality needs!

Will Heaton

DiscGenics

The Osmotech XT provides data integrity compliance, ensuring the reliability and accuracy of our results. The ease of use, great value for money, and exceptional after-sales service have significantly improved our processes. The support team is always available for any questions, provided on-site training, and continues to assist with upgrades as needed. I highly recommend this instrument to anyone in the field.

Caitlin Wint

Validation Manager at cutting edge cell therapy developer

During expansion, we use InstiSHAKE CHO to support the adaptation of our clones to shaking culture. Thanks to InstiSHAKE CHO, we have significantly reduced the number of clones lost (by 90%) and have reduced the amount of time taken for cells to reach our desired viable cell density and viability by 7 days.  Taken together, the combined use of InstiGRO CHO and InstiSHAKE CHO can accelerate our CLD workflow up to 3 weeks with little compromise to productivity. 

CHO+PLUS

We use InstiGRO CHO to improve the efficiency of our cloning projects. The supplement has helped us achieve clonal outgrowth >80% and has reduced the time taken for clones to reach our desired confluence by 2 weeks! Taken together, the combined use of InstiGRO CHO and InstiSHAKE CHO can accelerate our CLD workflow up to 3 weeks with little compromise to productivity. 

CHO+PLUS

Once we brought [the Artel MVS] into the lab, we realized we could push to small volumes. We typically work beyond the liquid handler’s specifications, and we can do this because we have Artel to verify their performance.

Robert Grbac

SEKISUI XenoTech

The Artel MVS System has greatly improved our laboratory quality processes, not only streamlining instrument qualifications but accelerating verification and validations.

Chris Trefill

SummerBio

We rely on the MVS for verifications and liquid class development and optimization…

Thai Truong

Janssen R&D

The [Artel MVS] simplified and streamlined our QC process…

Natalie Grow

Bristol-Meyers Squibb

The MVS system has been vital to our lab operations.

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

In the beginning, you never know which kind of samples you’re going to test, and the [OsmoTECH XT] osmometer offers an amazing range of osmolality testing: from 0 to 4000 mOsm/kg H2O.

Kayla Pasake

The Center for Breakthrough Medicines

Osmolality testing is crucial for process development, analytical development and GMP testing. We need to meet the regulatory requirements [with the OsmoTECH XT] for the product to be released to the market or to be released to go to a patient.

Kayla Pasake

The Center for Breakthrough Medicines

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Shweta Nair

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Director - Biopharma Osmometer Portfolio