Osmometers

We have a legacy of producing high-quality osmometers that have helped bioprocessing, clinical, food & beverage, and academic labs improve quality, achieve reliable outcomes, and increase productivity for more than 65 years.

Tailored to Support Industry Spanning Osmolality Applications

Osmolality testing is crucial in bioprocessing and clinical diagnostics, ensuring pharmaceutical quality control and aiding in patient care.

Essential for FDA-mandated biological drug release, osmolality oversees bioprocessing from development to final product checks. Our advanced osmometers facilitate accurate and swift results.

In clinical applications, osmolality testing is vital for diagnosing conditions like toxic alcohol ingestion and hyponatremia, and managing osmotically active therapies. Our osmometers help labs uphold healthcare and pharmaceutical standards, ensuring patient safety and effective treatments.

 

Bioprocessing Osmometers   Clinical Osmometers

 

Bioprocessing Osmometers

Across development and manufacturing workflows, our bioprocessing osmometers ensure consistency in product yield, purity and quality

Whether you need insight into process development or product quality, our osmometers deliver unmatched quality, performance, and reliability.

  • Our entire portfolio of OsmoTECH® osmometers provide you with the speed and precision of freezing point technology.
  • Each of our easy-to-use instruments is thoughtfully optimized for bioprocessing and readily fits into any workflow from process development through GMP manufacturing.

Compare Bioprocessing Osmometers

Clinical Osmometers

We continue to improve our clinical osmometers by responding to the demands of everchanging hospital laboratory environments with new, industry leading technologies..

Our portfolio of clinical osmometers deliver the ease-of-use features demanded by hospital labs to ensure they stay productive.

Easily integrated into any lab workflow, our instruments offer the level of automation needed to ensure maximum productivity, so labs can handle any level of patient sample testing in an efficient manner.

With increasing levels of staff shortages and continued challenges, this is of utmost importance.

Compare Clinical Osmometers

Bioprocessing Osmometers

OsmoTECH® XT Single-Sample Osmometer

LEARN MORE

OsmoTECH® PRO Multi-Sample Micro-Osmometer

LEARN MORE

OsmoTECH® HT Automated Micro-Osmometer

LEARN MORE

Bioprocess Calibrators and Controls

LEARN MORE

Clinical Osmometers

OsmoPRO® MAX Automated Osmometers

LEARN MORE

Osmo1® Single-Sample Micro-Osmometer

LEARN MORE

OsmoPRO® Multi-Sample Micro-Osmometer

LEARN MORE

Clinical Calibrators and Controls

LEARN MORE

What our customers say

Advanced Instruments Osmo 1 Single [sample osmometer] is an exceptional product. It is user friendly and easy to train new employees and students. The user guide is extremely detailed and thorough and easy to follow along. The instrument is reliable and using only faults due to human error. Great product!

Lacey Campbell

Springhill Medical Center

[The OsmoTECH XT is] easy to use, reliable and self-navigating options menu.

Alexander Shapiro

Precision NanoSystems

Osmolality testing is crucial for process development, analytical development and GMP testing. We need to meet the regulatory requirements [with the OsmoTECH XT] for the product to be released to the market or to be released to go to a patient.

Kayla Pasake

The Center for Breakthrough Medicines

The main advantage offered by the OsmoPRO MAX over our existing machines is the ability to load the samples and then walk away – currently our staff have to sit with the existing equipment until the test is completed. With workloads going up and pressures on staffing that feature is really valuable and was the biggest benefit for our laboratory.”

Debra Beesley

Lead Biomedical Scientist, Clinical Biochemistry, Royal Preston Hospital

The OsmoPRO MAX was very easy to use. I had minimal training and was able to easily navigate around the various screens within the software. The software was very user friendly and it’s good that it was very similar to the OsmoPRO software so it felt familiar. Our other members of staff found it very easy to use.

Katie Hicks

Senior Biomedical Scientist, University Hospital of Wales, Cardiff and Vale University Health Board

[The OsmoTECH PRO is] very easy to use for all technicians in a quality control lab. Small sample size. Friendly technicians that explained how to use the product very well.

Cathy Gladkowski

Biologos LLC

The best part of the [OsmoTECH] instrument is it gives accurate and reproducible results for any solution and most importantly in less than a minute you have the results.

Brijeshkumar Pandya

Nivagen Pharmaceuticals Inc.

[The OsmoTECH PRO is a] great system for multiple sample testing. Very straightforward and easy to use.

Bobby Grigoropoulos

Fresenius Kabi USA

The Osmo1 follows in the footsteps of its predecessors like the 3250. The introduction of barcode scanning and touch screen has provided better functionality and connectivity. The device has rock solid performance and uses the same supplies as the 3250. Advanced Instruments is definitely the market leader when it comes to osmolality measurement with accurate results for patient clinical use in a 24/7 environment.

Ken Onuska

Halton Healthcare

The [Osmo1] is a valuable tool within our facility. The set up was extremely easy. There are a lot of features for programming if you require passwords for individual users or if you just want any lab personnel to be able to run a sample. ... . Maintenance is easy to perform, it is not time consuming, or something you need to dig out the manual for complex instructions. The supply pack has a sensor in it so when consumables need to be replaced it will auto-update the supplies and alert when supplies are >50...

Judy McCormick

Meno Ya Win Hospital

This [OsmoTECH] instrument was a dream come true. The administrator can lock down features and dictate what users can and cannot do. Very easy to use and extremely reliable instrument.

Troy Franz

Paragon Bioservices

The [OsmoTECH] is highly effective and obtained results are of high quality. With this instrument I can develop my formulation for meeting the osmolality criteria for drug products.

Siva Bingi

Intas Pharmaceuticals

[The OsmoTECH] achieves high quality and reproducible results. Easy instrument to use and well-presented software.

Claudia Chadford

Touchlight Genetics

[The OsmoTECH is] easy to use and robust piece of equipment that met all our user and regulatory requirements. The hardware is sleek, efficient and easy to use. The integrated software has built in data integrity controls and is thoroughly tested through validation test scripts / reports.

J. Lacey

Replimune

[The OsmoTECH PRO] instrument is simple to operate with minimal consumables.

Greg Hautke

Baxter Healthcare

This [OsmoTECH PRO] osmometer is an accurate and convenient tool for the needs of our lab. Our lab works in the developmental stage of pharmaceuticals, and requires quick, precise bursts of osmolality checking for QC - and this instrument (with a load capacity of 20 samples) takes care of those needs. With developmental drugs, limited sample volume is often an issue - this instrument only needs 30uL (and takes ~90 seconds a measurement).

Sasha Sheptovitsky

Alexion Pharmaceuticals

Osmolality measurements are easy and reliable with this [OsmoTECH PRO] instrument.

Kevin Kent

Boehringer-ingelheim

[The OsmoTECH PRO is an] excellent product and extremely efficient! Easy to clean and maintain. Excellent customer support and allows increased in-process testing capabilities.

Seth Rindner

Biologos LLC

[The OsmoTECH PRO is] very easy to use due to short analysis time and sample preparation.

Karthik Venkatachalam

Pfizer

The [OsmoTECH PRO] is very easy to use. Allows my lab to update a 20+ year old instrument, also from Advanced.

Walter Wasylenko

Baxter Healthcare Corporation

In the beginning, you never know which kind of samples you’re going to test, and the [OsmoTECH XT] osmometer offers an amazing range of osmolality testing: from 0 to 4000 mOsm/kg H2O.

Kayla Pasake

The Center for Breakthrough Medicines

[The OsmoTECH XT is a] robust and versatile instrument that meets all of our osmolality needs!

Will Heaton

DiscGenics

[Protinol and Renol produce] great results with the analyzer we use. Excellent quality and easy to use.

Audra Wilson

Meadows Regional Medical Center

Focused on Customers Since 1955

Since 1955

Headquartered in Norwood Massachusetts, Advanced Instruments has spent 65+ years designing systems that help global customers improve product quality and safety, meet regulatory requirements, and reduce costs.

Experts in Freezing Point Depression

Our first products commercialized freezing-point depression technology, bringing the advantages of electronic automation to the lab (a big innovation for 1955!). Freezing-point depression technology was a classical method for solute concentration studies in dairy testing and Advanced Instruments helped establish the method with nephrologists, making it a staple of laboratory medicine.

A Trusted Advisor

Since that time, laboratory professionals have looked to Advanced Instruments for exceptional customer support and leading edge tools for bioprocessing development & drug manufacturing, clinical diagnostics and food & beverage quality control. Our solutions offer alternatives to the status quo, meeting lab and process challenges with practical innovations.

Award Winning Products