Ask the Expert: Osmolality – A Key Quality Attribute in Cell Therapy Production

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Osmolality has long been recognized as a critical quality attribute (CQA) in bioprocessing, encompassing both upstream and downstream workflows. Historically, osmolality measurement has been utilized in protein-based biologics development and manufacturing. It is also crucial for the development and production of cell therapies.

The significance of osmolality testing spans every stage of cell therapy production, from early process development and cell selection to transfection, verification, cryopreservation, storage, and formulation. Osmolality is a quick test that provides versatile information across all phases of cell therapy production about the process efficiency and quality of product.

In this Ask the Expert we spoke with Shweta Nair, Director, OsmoBio Product Portfolio at Advanced Instruments about the relationship between osmolality and cell therapy with a transcript of our interview below.

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