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Clinical Overview Emergency Medicine Internal Medicine/Endocrinology


Osmolality provides information that is unobtainable by any other method, and it contributes dimension to other laboratory parameters. Osmometry is critical in improving patient care by enabling clinicians to make more timely diagnoses and institute more appropriate patient care, which translates to decreased health care costs for medical institutions of any size, in any setting.

Osmolality, as determined by freezing-point depression, is the preferred method for clinical application. Other methods are insensitive to volatile solutes, and can give misleading results in toxicology and evaluation of diabetic complications. Today’s freezing-point osmometers offer tighter performance CVs, leading the College of American Pathologists to recognize a distinct category of results in performance surveys.